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- Bcef39d92377224d06968d6388a53de82 NCIT_P378 "NCI" @default.
- Bcef39d92377224d06968d6388a53de82 type Axiom @default.
- Bcef39d92377224d06968d6388a53de82 annotatedProperty IAO_0000115 @default.
- Bcef39d92377224d06968d6388a53de82 annotatedSource NCIT_C48032 @default.
- Bcef39d92377224d06968d6388a53de82 annotatedTarget "The mesylate salt form of ziprasidone, a benzothiazolylpiperazine derivative and an atypical antipsychotic agent with an antischizophrenic property. Ziprasidone mesylate functions as an antagonist at the dopamine D2 and serotonin 5-HT2A and 5-HT1D receptors, and as an agonist at the 5-HT1A receptor. Ziprasidone mesylate also inhibits the synaptic reuptake of serotonin and norepinephrine. The mechanism of action by which ziprasidone mesylate exerts its antischizophrenic effect is unknown but is potentially mediated through a combination of dopamine D2 and serotonin 5-HT2 antagonism. This agent also has antagonistic activity against histamine H1 and alpha-1-adrenergic receptors." @default.