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- Bcf785aaeca51d28bcf7619d158226b60 NCIT_P378 "NCI" @default.
- Bcf785aaeca51d28bcf7619d158226b60 type Axiom @default.
- Bcf785aaeca51d28bcf7619d158226b60 annotatedProperty IAO_0000115 @default.
- Bcf785aaeca51d28bcf7619d158226b60 annotatedSource NCIT_C1168 @default.
- Bcf785aaeca51d28bcf7619d158226b60 annotatedTarget "A synthetic bis-ethyl analogue of spermine with potential antineoplastic activity. N(1),N(11)-bis(ethyl)norspermine (DENSPM), a N-terminally alkylated tetraamine and polyamine mimetics, disrupts polyamine pool homeostasis by modulating the activities of the biosynthetic enzymes, ornithine decarboxylase (ODC), and S-adenosylmethionine decarboxylase (AdoMetDC). This agent also reduces polyamine concentrations through the induction of the catabolic enzyme spermidine/spermine N1-acetyltransferase 1 (SSAT). Polyamines, an integral part of the DNA helix structure, play a critical role in cell division, differentiation and membrane function. Disruption of normal polyamine concentrations by DENSPM may lead to cell growth inhibition." @default.