Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/Bcfe87f152bd3b4cc5a9dd208c7ef91a3> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- Bcfe87f152bd3b4cc5a9dd208c7ef91a3 NCIT_P378 "NCI" @default.
- Bcfe87f152bd3b4cc5a9dd208c7ef91a3 type Axiom @default.
- Bcfe87f152bd3b4cc5a9dd208c7ef91a3 annotatedProperty IAO_0000115 @default.
- Bcfe87f152bd3b4cc5a9dd208c7ef91a3 annotatedSource NCIT_C47714 @default.
- Bcfe87f152bd3b4cc5a9dd208c7ef91a3 annotatedTarget "The hydrochloride salt form of selegiline, a levorotatory acetylenic derivative of phenethylamine with antiparkinsonian effect. As a selective monoamine oxidase (MAO) inhibitor, selegiline has the greatest affinity for type B MAO, found mainly in the brain. Selegiline is converted by MAO B to an active moiety, which binds irreversibly at the active site of the enzyme's cofactor FAD (flavin adenine dinucleotide) molecule. This prevents the oxidative deamination of catecholamines and serotonin by MAO B, and leads to an increase in these neurotransmitters' activities resulting in improved motor function. In addition, this agent may inhibit re-uptake of dopamine by the neuron and prolong dopamine activity." @default.