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- Bd036ec0bec92b775a5d778f466ac6b8e NCIT_P378 "NCI" @default.
- Bd036ec0bec92b775a5d778f466ac6b8e type Axiom @default.
- Bd036ec0bec92b775a5d778f466ac6b8e annotatedProperty IAO_0000115 @default.
- Bd036ec0bec92b775a5d778f466ac6b8e annotatedSource NCIT_C62005 @default.
- Bd036ec0bec92b775a5d778f466ac6b8e annotatedTarget "A derivative of dibenzocycloheptadiene and a tricyclic antidepressant. Amitriptyline inhibits the re-uptake of norepinephrine and serotonin by the presynaptic neuronal membrane in the central nervous system (CNS), thereby increasing the synaptic concentration of norepinephrine and serotonin. Due to constant stimulation to these receptors, amitriptyline may produce a downregulation of adrenergic and serotonin receptors, which may contribute to the antidepressant activity." @default.