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- Bd03ffcb5b452241dcb9a37bf028c2005 NCIT_P378 "NCI" @default.
- Bd03ffcb5b452241dcb9a37bf028c2005 type Axiom @default.
- Bd03ffcb5b452241dcb9a37bf028c2005 annotatedProperty IAO_0000115 @default.
- Bd03ffcb5b452241dcb9a37bf028c2005 annotatedSource NCIT_C29268 @default.
- Bd03ffcb5b452241dcb9a37bf028c2005 annotatedTarget "The furoate ester form of mometasone, a synthetic topical glucocorticoid receptor (GR) agonist with anti-inflammatory, anti-pruritic and vasoconstrictive properties. Upon administration, mometasone binds to cytoplasmic GRs and subsequently activates GR-mediated gene expression. This results in the synthesis of certain anti-inflammatory proteins, while inhibiting the synthesis of certain inflammatory mediators. Specifically, mometasone appears to induce phospholipase A2 inhibitory proteins, thereby controlling the release of the inflammatory precursor arachidonic acid from phospholipid membrane by phospholipase A2." @default.