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- Bd07abd455dd826c231d4c285f0ffd4cf NCIT_P378 "NCI" @default.
- Bd07abd455dd826c231d4c285f0ffd4cf type Axiom @default.
- Bd07abd455dd826c231d4c285f0ffd4cf annotatedProperty IAO_0000115 @default.
- Bd07abd455dd826c231d4c285f0ffd4cf annotatedSource NCIT_C68963 @default.
- Bd07abd455dd826c231d4c285f0ffd4cf annotatedTarget "A selective, orally active small molecule, targeting protein kinase B (PKB or AKT) and ribosomal protein S6 Kinase (p70S6K), with potential antineoplastic activity. XL418 inhibits the activities of PKB and p70S6K, both acting downstream of phosphoinosotide-3 kinase (PI3K). These kinases are often upregulated in a variety of cancers. Inhibition of PKB by this agent will induce apoptosis, while inhibition of p70S6K will result in the inhibition of translation within tumor cells." @default.