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- Bd0b05c5f18366376a1fb9422a02c4a6a NCIT_P378 "BIOCARTA" @default.
- Bd0b05c5f18366376a1fb9422a02c4a6a type Axiom @default.
- Bd0b05c5f18366376a1fb9422a02c4a6a annotatedProperty NCIT_P325 @default.
- Bd0b05c5f18366376a1fb9422a02c4a6a annotatedSource NCIT_C39140 @default.
- Bd0b05c5f18366376a1fb9422a02c4a6a annotatedTarget "LIS1 can bind to MT bundles; however, phospho-LIS1 binding to MT bundles is mediated through the distal zinc finger motif of CLIP-170. When the distal zinc finger motif of CLIP-170 is mutated, the phospho-LIS1 isoform can no longer bind to MT bundles. This can also explain why p150/dynactin is not recruited to the MT bundles. CLIP-170 targets the dynein/dynactin complex to the MT, using phopho-LIS1 as an adapter; the motor complex, being in the proximity of the MT, associates with it. The initial static link to the MT provided by CLIP-170 is released by its hyperphosphorylation and the retrograde dynein/dynactin-dependent movement of the cargo (endocytic vesicle, kinetochore, etc.) takes place. Doublecortin (DCX) is placed close to the LIS1 pathway based on its interaction with LIS1 and its role in microtubule dynamics. (This definition may be outdated - see the DesignNote.)" @default.