Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/Bd0e48f94a819fd7e04f139625af43f37> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- Bd0e48f94a819fd7e04f139625af43f37 NCIT_P378 "NCI" @default.
- Bd0e48f94a819fd7e04f139625af43f37 type Axiom @default.
- Bd0e48f94a819fd7e04f139625af43f37 annotatedProperty IAO_0000115 @default.
- Bd0e48f94a819fd7e04f139625af43f37 annotatedSource NCIT_C97936 @default.
- Bd0e48f94a819fd7e04f139625af43f37 annotatedTarget "Sulfonamide urea derivatives with antihyperglycemic activity. Sulphonylurea antidiabetic agents bind to sulfonylurea receptor type 1 (SUR1), the subunit of ATP-sensitive inwardly-rectifier potassium (IKATP) channels on the membranes of pancreatic beta cells, thereby blocking the inward current flow (influx) of positively charged K+ ions into the cell. This results in tonic membrane depolarization, and induces a calcium ion influx through voltage-sensitive calcium channels; increased intracellular calcium ion levels trigger exocytosis of insulin-containing granules. This eventually induces secretion of insulin. The IKATP channels found in pancreatic islets are complexes of four IKATP 6.2 and four SUR1 subunits. In addition, some sulfonylureas of larger molecular size may increase the sensitivity of peripheral tissues to insulin mediated through peroxisome proliferator-activated receptor gamma (PPARgamma)." @default.