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- Bd1a5ac34fe66fefe1bae07d9e4d29a78 NCIT_P378 "NCI" @default.
- Bd1a5ac34fe66fefe1bae07d9e4d29a78 type Axiom @default.
- Bd1a5ac34fe66fefe1bae07d9e4d29a78 annotatedProperty IAO_0000115 @default.
- Bd1a5ac34fe66fefe1bae07d9e4d29a78 annotatedSource NCIT_C102568 @default.
- Bd1a5ac34fe66fefe1bae07d9e4d29a78 annotatedTarget "A lipid microsphere (LM)-based formulation containing the poorly water soluble taxane docetaxel, a semi-synthetic analogue of paclitaxel, with antineoplastic activity. Docetaxel binds specifically to the beta-tubulin subunit of the microtubule, stabilizing tubulin and inhibiting microtubule disassembly, which causes cell cycle arrest at the G2/M phase and leads to cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and induces various mediators of the inflammatory response. Compared to docetaxel alone, the LM formulation may enhance stability, improve efficacy and may reduce toxicity; this formulation does not contain toxic detergents needed to solubilize docetaxel which further improves its side effect profile." @default.