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- Bd2312c9e90bcb3a4db3107dadc58f4a1 NCIT_P378 "NCI" @default.
- Bd2312c9e90bcb3a4db3107dadc58f4a1 type Axiom @default.
- Bd2312c9e90bcb3a4db3107dadc58f4a1 annotatedProperty IAO_0000115 @default.
- Bd2312c9e90bcb3a4db3107dadc58f4a1 annotatedSource NCIT_C102876 @default.
- Bd2312c9e90bcb3a4db3107dadc58f4a1 annotatedTarget "An orally available formulation containing an inhibitor of Bruton agammaglobulinemia tyrosine kinase (BTK), with potential antineoplastic activity. Upon administration, tirabrutinib covalently binds to BTK within B cells, thereby preventing B cell receptor signaling and impeding B cell development. As a result, this agent may inhibit the proliferation of B cell malignancies. BTK, a cytoplasmic tyrosine kinase and member of the Tec family of kinases, plays an important role in B lymphocyte development, activation, signaling, proliferation and survival." @default.