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- Bd2824c328a502a39ec94595c2d756a2c NCIT_P378 "NCI" @default.
- Bd2824c328a502a39ec94595c2d756a2c type Axiom @default.
- Bd2824c328a502a39ec94595c2d756a2c annotatedProperty IAO_0000115 @default.
- Bd2824c328a502a39ec94595c2d756a2c annotatedSource NCIT_C794 @default.
- Bd2824c328a502a39ec94595c2d756a2c annotatedTarget "A quinidine alkaloid isolated from the bark of the cinchona tree. Quinine has many mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism; disruption of DNA replication and transcription via DNA intercalation; and reduction of the excitability of muscle fibers via alteration of calcium distribution. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)" @default.