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- Bd2a1f57b6e5f89ffcab6c910396496e4 NCIT_P378 "NCI" @default.
- Bd2a1f57b6e5f89ffcab6c910396496e4 type Axiom @default.
- Bd2a1f57b6e5f89ffcab6c910396496e4 annotatedProperty IAO_0000115 @default.
- Bd2a1f57b6e5f89ffcab6c910396496e4 annotatedSource NCIT_C162375 @default.
- Bd2a1f57b6e5f89ffcab6c910396496e4 annotatedTarget "A competitive inhibitor for adenosine triphosphate (ATP) binding to polo-like kinase 1 (PLK1; PLK-1; STPK13), with potential antineoplastic activity. Upon administration, plogosertib selectively targets, binds to and inhibits PLK1, which disrupts mitosis and induces selective G2/M cell-cycle arrest followed by apoptosis in PLK1-overexpressing tumor cells. PLK1, named after the polo gene of Drosophila melanogaster, is a serine/threonine kinase that is crucial for the regulation of mitosis, and plays a key role in tumor cell proliferation, transformation and invasion. PLK1 expression is upregulated in a variety of tumor cell types and high expression is associated with increased aggressiveness and poor prognosis." @default.