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- Bd2b4834041dc5e800e0f064499a466f1 NCIT_P378 "NCI" @default.
- Bd2b4834041dc5e800e0f064499a466f1 type Axiom @default.
- Bd2b4834041dc5e800e0f064499a466f1 annotatedProperty IAO_0000115 @default.
- Bd2b4834041dc5e800e0f064499a466f1 annotatedSource NCIT_C104005 @default.
- Bd2b4834041dc5e800e0f064499a466f1 annotatedTarget "A biosimilar of pegfilgrastim, a long-acting pegylated form of recombinant human granulocyte colony-stimulating factor (G-CSF) filgrastim, with hematopoietic activity. In a similar manner to G-CSF, pegfilgrastim biosimilar LA-EP2006 binds to and activates specific cell surface receptors, stimulating neutrophil progenitor proliferation and differentiation and selected neutrophil functions. Therefore, this agent may prevent the incidence and shorten the duration of chemotherapy-induced neutropenia. Conjugation of the cytokine with a branched polyethylene glycol molecule significantly increases this agent's therapeutic half-life compared to filgrastim." @default.