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- Bd2d6c6c11369745a9a6602034091fcf9 NCIT_P378 "NCI" @default.
- Bd2d6c6c11369745a9a6602034091fcf9 type Axiom @default.
- Bd2d6c6c11369745a9a6602034091fcf9 annotatedProperty IAO_0000115 @default.
- Bd2d6c6c11369745a9a6602034091fcf9 annotatedSource NCIT_C53434 @default.
- Bd2d6c6c11369745a9a6602034091fcf9 annotatedTarget "A phytonutrient and plant indole found in cruciferous vegetables including broccoli, Brussels sprouts, cabbage, cauliflower and kale, with potential anti-androgenic and antineoplastic activities. As a dimer of indole-3-carbinol, diindolylmethane (DIM) promotes beneficial estrogen metabolism in both sexes by reducing the levels of 16-hydroxy estrogen metabolites and increasing the formation of 2-hydroxy estrogen metabolites, resulting in increased antioxidant activity. Although this agent induces apoptosis in tumor cells in vitro, the exact mechanism by which DIM exhibits its antineoplastic activity in vivo is unknown." @default.