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- Bd40d994fb9fb19ae5a934c74783269aa NCIT_P378 "NCI" @default.
- Bd40d994fb9fb19ae5a934c74783269aa type Axiom @default.
- Bd40d994fb9fb19ae5a934c74783269aa annotatedProperty IAO_0000115 @default.
- Bd40d994fb9fb19ae5a934c74783269aa annotatedSource NCIT_C94218 @default.
- Bd40d994fb9fb19ae5a934c74783269aa annotatedTarget "An autologous dendritic cell (DC) cancer vaccine with potential immunostimulatory activity. Anti-CTLA4 MoAb RNA/GITRL RNA-transfected DC vaccine is prepared by transfecting DCs with RNAs encoding humanized heavy and light chains of the anti-CTLA4 (cytotoxic T-Lymphocyte-Associated Antigen 4) monoclonal antibody and tumor necrosis factor (ligand) superfamily, member 18 (TNFSF18 or GlTRL); expression of anti-CTLA4 blocks the inhibitory effect of CTLA4 on the activation of T-lymphocytes, while expression of GlTRL modulates T lymphocyte survival in peripheral tissues. Co-vaccination of this vaccine with melanoma antigen specific vaccine may eliminate the adverse effects associated with systemic administration of immune modulators, while also enhancing vaccine-induced immune responses." @default.