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- Bd46d6a08fb73a8f56d6954bdcf54414e NCIT_P378 "NCI" @default.
- Bd46d6a08fb73a8f56d6954bdcf54414e type Axiom @default.
- Bd46d6a08fb73a8f56d6954bdcf54414e annotatedProperty IAO_0000115 @default.
- Bd46d6a08fb73a8f56d6954bdcf54414e annotatedSource NCIT_C40818 @default.
- Bd46d6a08fb73a8f56d6954bdcf54414e annotatedTarget "Multidrug Resistance Inhibition involves interference with, or restraint of, the activities of biologic molecules or complexes involved in processes that increase the ability of cancer cells to counteract, defeat, or withstand the effects of multiple chemotherapeutic agents. Mechanisms involve decreased expression of multidrug efflux pumps (p-glycoprotein), altered glutathione metabolism, increased topoisomerase II activity, and changes in various cellular proteins. Inhibition results in increased transport of drug into, or decreased transport out of, cells and increased effectiveness of chemotherapeutic agents." @default.