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- Bd51912d87a041500b3fc6c799ac48c05 NCIT_P378 "NCI" @default.
- Bd51912d87a041500b3fc6c799ac48c05 type Axiom @default.
- Bd51912d87a041500b3fc6c799ac48c05 annotatedProperty IAO_0000115 @default.
- Bd51912d87a041500b3fc6c799ac48c05 annotatedSource NCIT_C176028 @default.
- Bd51912d87a041500b3fc6c799ac48c05 annotatedTarget "A bispecific monoclonal antibody against both the tumor-associated antigen (TAA) human mucin 16 (MUC16, cancer antigen 125; CA125; FLJ14303) and the co-stimulatory T-cell-specific surface glycoprotein CD28, with potential antineoplastic and immunostimulating activities. Upon administration, anti-MUC16/CD28 bispecific antibody REGN5668 binds to both CD28 on T-cells and MUC16-expressing tumor cells, which cross-links the T-cells to the tumor cells. This may result in a potent cytotoxic T-lymphocyte (CTL) response against the MUC16-expressing tumor cells. MUC16, a member of the mucin family of glycoproteins, is overexpressed by several epithelial cancers, including ovarian cancer." @default.