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- Bd5392b6917bcf33fb7c89b858592328f NCIT_P378 "NCI" @default.
- Bd5392b6917bcf33fb7c89b858592328f type Axiom @default.
- Bd5392b6917bcf33fb7c89b858592328f annotatedProperty IAO_0000115 @default.
- Bd5392b6917bcf33fb7c89b858592328f annotatedSource NCIT_C47690 @default.
- Bd5392b6917bcf33fb7c89b858592328f annotatedTarget "The hydrochloride salt form of proguanil, a synthetic biguanide derivative of pyrimidine and an folate antagonist with antimalarial property. Upon hydrolysis, proguanil is converted to its active cyclic triazine metabolite, cycloguanil, by a cytochrome P450 dependent reaction. Cycloguanil selectively inhibits the bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) of plasmodium parasite, thereby disrupting deoxythymidylate synthesis and ultimately blocking DNA and protein synthesis in the parasite." @default.