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- Bd5639c413a4f68a59c5f7a13a300cf5b NCIT_P378 "NCI" @default.
- Bd5639c413a4f68a59c5f7a13a300cf5b type Axiom @default.
- Bd5639c413a4f68a59c5f7a13a300cf5b annotatedProperty IAO_0000115 @default.
- Bd5639c413a4f68a59c5f7a13a300cf5b annotatedSource NCIT_C114500 @default.
- Bd5639c413a4f68a59c5f7a13a300cf5b annotatedTarget "An antibody drug conjugate (ADC) containing a human monoclonal antibody AGS-22 targeting the cell adhesion molecule nectin-4 and conjugated to the cytotoxic agent monomethyl auristatin E (MMAE), via a proprietary enzyme-cleavable linker (AGS-22CE), with potential antineoplastic activity. The monoclonal antibody moiety of enfortumab vedotin selectively binds to nectin-4. After internalization and proteolytic cleavage, MMAE binds to tubulin and inhibits its polymerization, which results in G2/M phase arrest and induces apoptosis in nectin-4 overexpressing tumor cells. Nectin-4, a tumor associated antigen belonging to the nectin family, is overexpressed in a variety of cancers, including breast, bladder, lung and pancreatic cancer." @default.