Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/Bd5d646854a493c67f0c7960b51ec76fa> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- Bd5d646854a493c67f0c7960b51ec76fa NCIT_P378 "NCI" @default.
- Bd5d646854a493c67f0c7960b51ec76fa type Axiom @default.
- Bd5d646854a493c67f0c7960b51ec76fa annotatedProperty IAO_0000115 @default.
- Bd5d646854a493c67f0c7960b51ec76fa annotatedSource NCIT_C181768 @default.
- Bd5d646854a493c67f0c7960b51ec76fa annotatedTarget "A recombinant, humanized, agonistic monoclonal antibody targeting the B-cell surface antigen CD40, with potential immunostimulatory and antineoplastic activities. Upon administration, anti-CD40 agonist monoclonal antibody MIL97 targets and binds to CD40 on a variety of immune cell types. This induces CD40-dependent signaling pathways, triggers the proliferation and activation of antigen-presenting cells (APCs) and activates T-cells. This results in an enhanced cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells. CD40, a cell surface receptor and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on various immune cells, such as dendritic cells (DCs), macrophages and B-cells, and plays a key role in the activation of the immune system." @default.