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- Bd62095ff9dcf4c6b4d08df589248323b NCIT_P378 "NCI" @default.
- Bd62095ff9dcf4c6b4d08df589248323b NCIT_P381 "http://research.medicine.wustl.edu" @default.
- Bd62095ff9dcf4c6b4d08df589248323b type Axiom @default.
- Bd62095ff9dcf4c6b4d08df589248323b annotatedProperty IAO_0000115 @default.
- Bd62095ff9dcf4c6b4d08df589248323b annotatedSource NCIT_C21518 @default.
- Bd62095ff9dcf4c6b4d08df589248323b annotatedTarget "These genes encode more than 30 proteins of the complement system engaged in host defense. This system provides both an independent immune system capable of attacking microbes as well as other foreign material and an adjunct to the antibody system. Once activated, the complement system fires in a cascade-like fashion in which one component activates the next. Both swift and powerful, millions of complement components can deposit on an invading microbe within only a few minutes. Such a potent system requires strict regulation to avoid host injury. Membrane cofactor protein (MCP) is one critical regulator aimed at controlling inadvertent complement activation on host cells and nearly every cell examined expresses MCP on its cell membrane." @default.