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- Bd6242c0b0e7c5971fb1f5e203e7ba650 NCIT_P378 "NCI" @default.
- Bd6242c0b0e7c5971fb1f5e203e7ba650 type Axiom @default.
- Bd6242c0b0e7c5971fb1f5e203e7ba650 annotatedProperty IAO_0000115 @default.
- Bd6242c0b0e7c5971fb1f5e203e7ba650 annotatedSource NCIT_C113787 @default.
- Bd6242c0b0e7c5971fb1f5e203e7ba650 annotatedTarget "An inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFK-2/FBPase) isoform 3 (PFKFB3) and derivative of 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one (3PO), with potential antineoplastic activity. Upon administration, PFKFB3 inhibitor PFK-158 binds to and inhibits the activity of PFKFB3, which leads to the inhibition of both the glycolytic pathway in and glucose uptake by cancer cells. This prevents the production of macromolecules and energy that causes the enhanced cellular proliferation in cancer cells as compared to that of normal, healthy cells. Depriving cancer cells of nutrients and energy leads to the inhibition of cancer cell growth. PFKFB3, an enzyme that catalyzes the conversion of fructose-6-phosphate to fructose-2,6-bisphosphate, is highly expressed and active in human cancer cells; it plays a key role in increasing both glycolytic flux in and proliferation of cancer cells." @default.