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- Bd62eaca4487ca294fc5ba42434118875 NCIT_P378 "NCI" @default.
- Bd62eaca4487ca294fc5ba42434118875 type Axiom @default.
- Bd62eaca4487ca294fc5ba42434118875 annotatedProperty IAO_0000115 @default.
- Bd62eaca4487ca294fc5ba42434118875 annotatedSource NCIT_C1794 @default.
- Bd62eaca4487ca294fc5ba42434118875 annotatedTarget "A fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU); subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand. (NCI04)" @default.