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- Bd688f7739de3b750c7fedff79e468af3 NCIT_P378 "NCI" @default.
- Bd688f7739de3b750c7fedff79e468af3 type Axiom @default.
- Bd688f7739de3b750c7fedff79e468af3 annotatedProperty IAO_0000115 @default.
- Bd688f7739de3b750c7fedff79e468af3 annotatedSource NCIT_C61875 @default.
- Bd688f7739de3b750c7fedff79e468af3 annotatedTarget "An amino- bisphosphonate with anti-resorptive and anti-hypercalcemic activities. Pamidronic acid binds to and adsorbs onto hydroxyapatite crystals in the bone matrix, thereby preventing osteoclast resorption. This agent also binds to and inhibits farnesyl pyrophosphate synthase, an enzyme that plays an important role in the mevalonate pathway. This inhibits the formation of isoprenoid metabolites that are substrates for protein prenylation. This prevents farnesylation and geranylgeranylation of proteins essential for osteoclast function, leading to the induction of apoptosis of osteoclasts. By preventing osteoclast-mediated bone resorption, pamidronic acid decreases bone turnover rate, stabilizes the bone matrix and reduces hypercalcemia." @default.