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- Bd6c6e1be266a03521522e26ec74d800e NCIT_P378 "NCI" @default.
- Bd6c6e1be266a03521522e26ec74d800e type Axiom @default.
- Bd6c6e1be266a03521522e26ec74d800e annotatedProperty IAO_0000115 @default.
- Bd6c6e1be266a03521522e26ec74d800e annotatedSource NCIT_C65539 @default.
- Bd6c6e1be266a03521522e26ec74d800e annotatedTarget "The sodium salt of the S-isomer of omeprazole, with gastric proton pump inhibitor activity. In the acidic compartment of parietal cells, esomeprazole is protonated and converted into the active achiral sulfenamide; the active sulfenamide forms one or more covalent disulfide bonds with the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting its activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production. H+/K+ ATPase is an integral membrane protein of the gastric parietal cell." @default.