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- Bd6fea8c351e3a3c480e3c2d2baf96d39 NCIT_P378 "NCI" @default.
- Bd6fea8c351e3a3c480e3c2d2baf96d39 type Axiom @default.
- Bd6fea8c351e3a3c480e3c2d2baf96d39 annotatedProperty IAO_0000115 @default.
- Bd6fea8c351e3a3c480e3c2d2baf96d39 annotatedSource NCIT_C2398 @default.
- Bd6fea8c351e3a3c480e3c2d2baf96d39 annotatedTarget "An intravenous formulation of tretinoin (vitamin A acid or all-trans retinoic acid) encased in liposomes. Tretinoin is a naturally occurring retinoic acid agent that binds to and activates retinoic acid receptors (RAR), effecting changes in gene expression that lead to cell differentiation, decreased cell proliferation, and inhibition of carcinogenesis. This agent also inhibits telomerase, leading to telomere shortening and eventual apoptosis of certain tumor cell types. Liposome encapsulation extends the half-life of intravenously administered tretinoin." @default.