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- Bd7c22d63b04c72575dcbc96c02d97ade NCIT_P378 "NCI" @default.
- Bd7c22d63b04c72575dcbc96c02d97ade type Axiom @default.
- Bd7c22d63b04c72575dcbc96c02d97ade annotatedProperty IAO_0000115 @default.
- Bd7c22d63b04c72575dcbc96c02d97ade annotatedSource NCIT_C26422 @default.
- Bd7c22d63b04c72575dcbc96c02d97ade annotatedTarget "This region represents the germline organization of the immunoglobulin heavy chain locus. The locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several D and J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. (from LocusLink)" @default.