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- Bd7d6032bef35d1b29372e69389ce2b26 NCIT_P378 "KEGG" @default.
- Bd7d6032bef35d1b29372e69389ce2b26 type Axiom @default.
- Bd7d6032bef35d1b29372e69389ce2b26 annotatedProperty NCIT_P325 @default.
- Bd7d6032bef35d1b29372e69389ce2b26 annotatedSource NCIT_C91498 @default.
- Bd7d6032bef35d1b29372e69389ce2b26 annotatedTarget "Peroxisomes are essential organelles that play a key role in redox signaling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies." @default.