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- Bd815ed99de5d687bcb3b21d9e2904acc NCIT_P378 "NCI" @default.
- Bd815ed99de5d687bcb3b21d9e2904acc type Axiom @default.
- Bd815ed99de5d687bcb3b21d9e2904acc annotatedProperty IAO_0000115 @default.
- Bd815ed99de5d687bcb3b21d9e2904acc annotatedSource NCIT_C65272 @default.
- Bd815ed99de5d687bcb3b21d9e2904acc annotatedTarget "The sodium salt form of bromfenac, a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and anti-inflammatory activities. Upon ophthalmic administration, bromfenac binds to and inhibits the activity of cyclooxygenase II (COX II), an enzyme which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins (PG). By inhibiting PG formation, bromfenac is able to inhibit PG-induced inflammation, thereby preventing vasodilation, leukocytosis, disruption of the blood-aqueous humor barrier, an increase in vascular permeability and an increase in intraocular pressure (IOP)." @default.