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- Bd9333351952ce1e89dd8ad75d94fdbde hasDbXref "PMID:10954606" @default.
- Bd9333351952ce1e89dd8ad75d94fdbde hasDbXref "PMID:20660643" @default.
- Bd9333351952ce1e89dd8ad75d94fdbde type Axiom @default.
- Bd9333351952ce1e89dd8ad75d94fdbde annotatedProperty IAO_0000115 @default.
- Bd9333351952ce1e89dd8ad75d94fdbde annotatedSource FBcv_0003009 @default.
- Bd9333351952ce1e89dd8ad75d94fdbde annotatedTarget "Sequence change caused by the cleavage of specific DNA sequences by transcription activator-like effector nucleases (TALENs). TALEN proteins comprise a DNA binding domain fused to the catalytic domain of the FokI endonuclease. The DNA binding domain contains a repetitive region within the middle of the protein, consisting of tandem repeats of 34 amino acid segments, with each of these segments recognizing a single base pair. The specificity of the binding is determined by two hypervariable amino acids in positions 12 and 13 (repeat-variable diresidues). Cleavage requires dimerization of FokI. The endonuclease is directed to a target region by a pair of TALENs which bind to adjacent sequences separated by a spacer region, allowing dimerization and promoting cleavage." @default.