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- Bd961ed60009394c29eb3eb483ae93ce9 NCIT_P378 "NCI" @default.
- Bd961ed60009394c29eb3eb483ae93ce9 type Axiom @default.
- Bd961ed60009394c29eb3eb483ae93ce9 annotatedProperty IAO_0000115 @default.
- Bd961ed60009394c29eb3eb483ae93ce9 annotatedSource NCIT_C148145 @default.
- Bd961ed60009394c29eb3eb483ae93ce9 annotatedTarget "A radioconjugate composed of PSMA-617, a human prostate-specific membrane antigen (PSMA)-targeting ligand, conjugated to the beta-emitting radioisotope lutetium Lu 177 (177Lu), with potential antineoplastic activity against PSMA-expressing tumor cells. Upon intravenous administration of lutetium Lu 177 vipivotide tetraxetan, vipivotide tetraxetan targets and binds to PSMA-expressing tumor cells. Upon binding, PSMA-expressing tumor cells are destroyed by 177Lu through the specific delivery of beta particle radiation. PSMA, a tumor-associated antigen and type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells." @default.