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- Bd965cfa2214bcc5c365015b0483205c3 NCIT_P378 "NCI" @default.
- Bd965cfa2214bcc5c365015b0483205c3 type Axiom @default.
- Bd965cfa2214bcc5c365015b0483205c3 annotatedProperty IAO_0000115 @default.
- Bd965cfa2214bcc5c365015b0483205c3 annotatedSource NCIT_C201247 @default.
- Bd965cfa2214bcc5c365015b0483205c3 annotatedTarget "An orally bioavailable, covalent and selective inhibitor of FMS-like tyrosine kinase 3 (FLT3; CD135; STK1; FLK2), with potential antineoplastic activity. Upon oral administration, FLT3 inhibitor BMF-500 selectively targets and irreversibly binds to a reactive cysteine in the active site of FLT3. This inhibits the activity of FLT3 and prevents FLT3-mediated downstream signaling. This inhibits the proliferation of FLT3-expressing cancer cells. FLT3, a class III receptor tyrosine kinase (RTK), is overexpressed or mutated in most B-lineage neoplasms and in acute myeloid leukemias." @default.