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- Bd976044181a0499943d0e5771d3e3510 NCIT_P378 "NCI" @default.
- Bd976044181a0499943d0e5771d3e3510 type Axiom @default.
- Bd976044181a0499943d0e5771d3e3510 annotatedProperty IAO_0000115 @default.
- Bd976044181a0499943d0e5771d3e3510 annotatedSource NCIT_C792 @default.
- Bd976044181a0499943d0e5771d3e3510 annotatedTarget "A polyphenolic flavonoid with potential chemopreventive activity. Quercetin, ubiquitous in plant food sources and a major bioflavonoid in the human diet, may produce antiproliferative effects resulting from the modulation of either EGFR or estrogen-receptor mediated signal transduction pathways. Although the mechanism of action of action is not fully known, the following effects have been described with this agent in vitro: decreased expression of mutant p53 protein and p21-ras oncogene, induction of cell cycle arrest at the G1 phase and inhibition of heat shock protein synthesis. This compound also demonstrates synergy and reversal of the multidrug resistance phenotype, when combined with chemotherapeutic drugs, in vitro. Quercetin also produces anti-inflammatory and anti-allergy effects mediated through the inhibition of the lipoxygenase and cyclooxygenase pathways, thereby preventing the production of pro-inflammatory mediators." @default.