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- Bd9789c64767c52b5ab48952c60d11929 NCIT_P378 "NCI" @default.
- Bd9789c64767c52b5ab48952c60d11929 type Axiom @default.
- Bd9789c64767c52b5ab48952c60d11929 annotatedProperty IAO_0000115 @default.
- Bd9789c64767c52b5ab48952c60d11929 annotatedSource NCIT_C61754 @default.
- Bd9789c64767c52b5ab48952c60d11929 annotatedTarget "The active S-stereoisomer of the selective serotonin reuptake inhibitor (SSRI) citalopram with antidepressant, anti-obsessive-compulsive and antibulimic properties. Escitalopram inhibits the reuptake of the neurotransmitter serotonin (5-HT) at the serotonin reuptake pump of the neuronal membrane of the presynaptic cell, thereby increasing levels of 5-HT within the synaptic cleft and enhancing the actions of serotonin on 5HT1A autoreceptors. Unlike other SSRIs, escitalopram appears to not only bind to a primary high-affinity site on the serotonin transporter protein but also to a secondary lower-affinity allosteric site that is considered to stabilize and prolong drug binding." @default.