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- Bd9a6fb6da6c1719625d1e9fdf749aabc NCIT_P378 "NCI" @default.
- Bd9a6fb6da6c1719625d1e9fdf749aabc type Axiom @default.
- Bd9a6fb6da6c1719625d1e9fdf749aabc annotatedProperty IAO_0000115 @default.
- Bd9a6fb6da6c1719625d1e9fdf749aabc annotatedSource NCIT_C2051 @default.
- Bd9a6fb6da6c1719625d1e9fdf749aabc annotatedTarget "A highly cytotoxic macrocyclic lactone polyether with antitumor activity. Spongistatin, originally isolated from marine Spongia species, binds to the vinca domain of tubulin, thereby interferes with microtubule assembly and results in inhibition of mitosis. This agent does not affect the binding of colchicine to tubulin, but it was a potent inhibitor of the binding of vinblastine and GTP to tubulin." @default.