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- Bda4e33e4976ece552eba5c6eadf9ca25 NCIT_P378 "NCI" @default.
- Bda4e33e4976ece552eba5c6eadf9ca25 type Axiom @default.
- Bda4e33e4976ece552eba5c6eadf9ca25 annotatedProperty IAO_0000115 @default.
- Bda4e33e4976ece552eba5c6eadf9ca25 annotatedSource NCIT_C72738 @default.
- Bda4e33e4976ece552eba5c6eadf9ca25 annotatedTarget "The hydrochloride salt form of dexmedetomidine, an imidazole derivate and active d-isomer of medetomidine with analgesic, anxiolytic and sedative activities. Dexmedetomidine selectively binds to and activates presynaptic alpha-2 adrenoceptors located in the brain, thereby inhibiting the release of norepinephrine from synaptic vesicles. This leads to an inhibition of postsynaptic activation of adrenoceptors, which inhibits sympathetic activity, thereby leading to analgesia, sedation and anxiolysis." @default.