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- Bda80250bbeddb313151fade9ba6e943d NCIT_P378 "NCI" @default.
- Bda80250bbeddb313151fade9ba6e943d type Axiom @default.
- Bda80250bbeddb313151fade9ba6e943d annotatedProperty IAO_0000115 @default.
- Bda80250bbeddb313151fade9ba6e943d annotatedSource NCIT_C65381 @default.
- Bda80250bbeddb313151fade9ba6e943d annotatedTarget "A phenylpiperidine with antidiarrheal activity and an active metabolite of diphenoxylate. Difenoxin is chemically related to the narcotic opioid meperidine. Difenoxin acts primarily on the gastrointestinal wall by binding to opioid receptors on acetylcholine-containing nerves and inhibiting the release of acetylcholine from presynaptic nerve terminals. This leads to a reduction in intestinal motility. Difenoxin hydrochloride also mimics the action of endogenous opioid peptides at the CNS opioid receptors, (primarily mu-receptors), thereby inducing CNS effects." @default.