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- Bdaa7a9848fe78632daf0b6e9c3f55923 NCIT_P378 "NCI" @default.
- Bdaa7a9848fe78632daf0b6e9c3f55923 type Axiom @default.
- Bdaa7a9848fe78632daf0b6e9c3f55923 annotatedProperty IAO_0000115 @default.
- Bdaa7a9848fe78632daf0b6e9c3f55923 annotatedSource NCIT_C47662 @default.
- Bdaa7a9848fe78632daf0b6e9c3f55923 annotatedTarget "The sodium salt of pentobarbital, a short-acting barbituric acid derivative with central nervous system (CNS) depressant property. Pentobarbital sodium binds to the gamma-aminobutyric acid (GABA)-A subtype receptor, resulting in modulation of chloride transport through receptor channels and potentiation of GABA-induced increases in chloride conductance. This enhances postsynaptic responses to the inhibitory actions of GABA and causes CNS depression. In addition, this agent inhibits glutamate induced nerve depolarization and depresses voltage-activated calcium currents." @default.