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- Bdac928e19fe05035eead366ab5a2cb86 NCIT_P378 "NCI" @default.
- Bdac928e19fe05035eead366ab5a2cb86 type Axiom @default.
- Bdac928e19fe05035eead366ab5a2cb86 annotatedProperty IAO_0000115 @default.
- Bdac928e19fe05035eead366ab5a2cb86 annotatedSource NCIT_C181997 @default.
- Bdac928e19fe05035eead366ab5a2cb86 annotatedTarget "An orally available inhibitor of the oncogenic KRAS substitution mutation, G12C, with potential antineoplastic activity. Upon oral administration, KRAS G12C inhibitor BI 1823911 selectively targets, binds to and inhibits the activity of the KRAS G12C mutant, thereby inhibiting KRAS G12C mutant-dependent signaling. KRAS, a member of the RAS family of oncogenes, serves an important role in cell signaling, division and differentiation. Mutations of KRAS may induce constitutive signal transduction leading to tumor cell growth, proliferation, invasion, and metastasis." @default.