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- Bdadac0844d05b60a2848f8d48d34bb81 NCIT_P378 "NCI" @default.
- Bdadac0844d05b60a2848f8d48d34bb81 type Axiom @default.
- Bdadac0844d05b60a2848f8d48d34bb81 annotatedProperty IAO_0000115 @default.
- Bdadac0844d05b60a2848f8d48d34bb81 annotatedSource NCIT_C101523 @default.
- Bdadac0844d05b60a2848f8d48d34bb81 annotatedTarget "A proprietary, hypoxia-activated prodrug with potential antineoplastic activity. Upon administration, the hypoxia-activated prodrug TH-4000 is activated in the hypoxic cells within tumors into an irreversible pan-HER inhibitor via a mechanism of action not yet fully elucidated. As a result, this agent inhibits cellular proliferation and differentiation of tumor cells overexpressing HER kinases, which belong to the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. Healthy, normal tissues may be spared due to the hypoxia-specific activity of this agent, potentially reducing systemic toxicity." @default.