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- Bdaf51afb6e6141854c0cb146181999e4 NCIT_P378 "NCI" @default.
- Bdaf51afb6e6141854c0cb146181999e4 type Axiom @default.
- Bdaf51afb6e6141854c0cb146181999e4 annotatedProperty IAO_0000115 @default.
- Bdaf51afb6e6141854c0cb146181999e4 annotatedSource NCIT_C1652 @default.
- Bdaf51afb6e6141854c0cb146181999e4 annotatedTarget "An orally-active synthetic hydroxamate with potential antineoplastic activity. Marimastat covalently binds to the zinc(II) ion in the active site of matrix metalloproteinases (MMPs), thereby inhibiting the action of MMPs, inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. This agent may also inhibit tumor necrosis factor-alpha converting enzyme (TACE), an enzyme involved in tumor necrosis factor alpha (TNF-alpha) production that may play a role in some malignancies as well as in the development of arthritis and sepsis. (NCI04)" @default.