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- Bdb17d12db02af306d7b08a4cb4ae8881 NCIT_P378 "NCI" @default.
- Bdb17d12db02af306d7b08a4cb4ae8881 type Axiom @default.
- Bdb17d12db02af306d7b08a4cb4ae8881 annotatedProperty IAO_0000115 @default.
- Bdb17d12db02af306d7b08a4cb4ae8881 annotatedSource NCIT_C127116 @default.
- Bdb17d12db02af306d7b08a4cb4ae8881 annotatedTarget "An orally available and selective inhibitor of the receptor tyrosine kinase AXL (UFO), with potential antineoplastic activity. Upon administration, dubermatinib targets and binds to AXL and prevents its activity. This blocks AXL-mediated signal transduction pathways and inhibits the epithelial-mesenchymal transition (EMT), which, in turn, inhibits tumor cell proliferation and migration. In addition, TP-0903 enhances chemo-sensitivity to certain other chemotherapeutic agents. AXL, a member of the Tyro3, AXL and Mer (TAM) family of receptor tyrosine kinases and overexpressed by many tumor cell types, plays a key role in tumor cell proliferation, survival, invasion and metastasis; its expression is associated with drug resistance and poor prognosis." @default.