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- Bdb1bf5cb06160c2ea19584df7f393edc NCIT_P378 "NCI" @default.
- Bdb1bf5cb06160c2ea19584df7f393edc type Axiom @default.
- Bdb1bf5cb06160c2ea19584df7f393edc annotatedProperty IAO_0000115 @default.
- Bdb1bf5cb06160c2ea19584df7f393edc annotatedSource NCIT_C48387 @default.
- Bdb1bf5cb06160c2ea19584df7f393edc annotatedTarget "A derivative of the natural macrocyclic lactone sirolimus with immunosuppressant and anti-angiogenic properties. In cells, everolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target of Rapamycin (mTOR), a key regulatory kinase. Inhibition of mTOR activation results in the inhibition of T lymphocyte activation and proliferation associated with antigen and cytokine (IL-2, IL-4, and IL-15) stimulation and the inhibition of antibody production. (NCI05)" @default.