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- Bdb6cd43d0f22ba434b30e1e2f9784cd3 NCIT_P378 "KEGG" @default.
- Bdb6cd43d0f22ba434b30e1e2f9784cd3 type Axiom @default.
- Bdb6cd43d0f22ba434b30e1e2f9784cd3 annotatedProperty NCIT_P325 @default.
- Bdb6cd43d0f22ba434b30e1e2f9784cd3 annotatedSource NCIT_C91483 @default.
- Bdb6cd43d0f22ba434b30e1e2f9784cd3 annotatedTarget "Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR." @default.