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- Bdb93e0937129b772ad6b0e88ebf2cdae NCIT_P378 "NCI" @default.
- Bdb93e0937129b772ad6b0e88ebf2cdae type Axiom @default.
- Bdb93e0937129b772ad6b0e88ebf2cdae annotatedProperty IAO_0000115 @default.
- Bdb93e0937129b772ad6b0e88ebf2cdae annotatedSource NCIT_C47687 @default.
- Bdb93e0937129b772ad6b0e88ebf2cdae annotatedTarget "The hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procaine. Procainamide hydrochloride reversibly binds to and blocks activated (open) voltage-gated sodium channels, thereby blocks the influx of sodium ions into the cell, which leads to an increase in threshold for excitation and inhibit depolarization during phase 0 of the action potential. In addition, the effective refractory period (ERP), action potential duration (APD), and ERP/APD ratios are increased, resulting in decreased impulse conduction velocity. The lasting action potential may also be due to blockage of outward K+ currents. The result is a decrease in automaticity, increase in refractory period and slowing of impulse conduction." @default.