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- Bdbd8c58f1d8c01626995da2e6ce129b0 NCIT_P378 "NCI" @default.
- Bdbd8c58f1d8c01626995da2e6ce129b0 type Axiom @default.
- Bdbd8c58f1d8c01626995da2e6ce129b0 annotatedProperty IAO_0000115 @default.
- Bdbd8c58f1d8c01626995da2e6ce129b0 annotatedSource NCIT_C66420 @default.
- Bdbd8c58f1d8c01626995da2e6ce129b0 annotatedTarget "A synthetic pyridinyl bisphosphonate with anti-resorptive activity. Although the exact mechanism of action has yet to be fully elucidated, piridronic acid likely binds to hydroxyapatite crystals in the bone matrix and inhibits farnesyl pyrophosphate synthase, an enzyme that plays an important role in the mevalonate pathway. This inhibits the formation of isoprenoid metabolites that are substrates for protein prenylation. This prevents farnesylation and geranylgeranylation of proteins essential for osteoclast function, leading to the induction of apoptosis and eventually, osteoclast-cell death. By preventing osteoclast-mediated bone resorption, piridronic acid decreases bone turnover and stabilizes the bone matrix." @default.