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- Bdc466b5394e3aa8b30a3d465fb7d8347 NCIT_P378 "NCI" @default.
- Bdc466b5394e3aa8b30a3d465fb7d8347 type Axiom @default.
- Bdc466b5394e3aa8b30a3d465fb7d8347 annotatedProperty IAO_0000115 @default.
- Bdc466b5394e3aa8b30a3d465fb7d8347 annotatedSource NCIT_C61590 @default.
- Bdc466b5394e3aa8b30a3d465fb7d8347 annotatedTarget "A non-toxic, small-molecule, hypoxia-activated, 3,5-dinitrobenzamide nitrogen mustard pre-prodrug with potential antitumor activity. Upon intravenous administration, PR-104 is converted by systemic phosphatases to the alcohol intermediate PR-104A, which is reduced to form the active DNA-crosslinking mustard species hydroxylamine PR-104H intracellularly under hypoxic conditions. PR-104H specifically crosslinks hypoxic tumor cell DNA, resulting in the inhibition of DNA repair and synthesis, cell-cycle arrest, and apoptosis in susceptible hypoxic tumor cell populations while sparing normoxic tissues." @default.