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- Bdc48ffa2433ef8c1cf58452f3f8dbfc5 NCIT_P378 "NCI" @default.
- Bdc48ffa2433ef8c1cf58452f3f8dbfc5 type Axiom @default.
- Bdc48ffa2433ef8c1cf58452f3f8dbfc5 annotatedProperty IAO_0000115 @default.
- Bdc48ffa2433ef8c1cf58452f3f8dbfc5 annotatedSource NCIT_C47390 @default.
- Bdc48ffa2433ef8c1cf58452f3f8dbfc5 annotatedTarget "The hydrochloride salt of amiloride, a synthetic pyrazine derivative with antikaliuretic and diuretic properties. Amiloride inhibits sodium channels located in the distal tubules and collecting ducts of the kidney, thereby preventing the absorption of sodium and increasing its excretion along with water, to produce naturesis. In response to the hypernatremic conditions in the kidney, the plasma membrane becomes hyperpolarized and electrochemical forces are reduced, which then prevents the excretion of potassium and hydrogen into the lumen." @default.