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- Bdc514c75008c04f9c5d1705472660db0 NCIT_P378 "NCI" @default.
- Bdc514c75008c04f9c5d1705472660db0 type Axiom @default.
- Bdc514c75008c04f9c5d1705472660db0 annotatedProperty IAO_0000115 @default.
- Bdc514c75008c04f9c5d1705472660db0 annotatedSource NCIT_C64773 @default.
- Bdc514c75008c04f9c5d1705472660db0 annotatedTarget "Human autologous peripheral blood lymphocytes (PBLs) transduced with an anti-p53 T cell receptor gene with potential antineoplastic activity. PBLs are harvested from a patient and pulsed with a retroviral vector that encodes the T-cell receptor gene specific for a mutated form of p53. The transduced PBLs are then expanded in culture. When reintroduced to the patient, these modified PBLs express the anti-p53 T cell receptor which binds to mutant p53-overexpressing tumor cells; PBL-mediated tumor growth inhibition may follow. Many tumor cell types overexpress mutant p53 proteins, which are associated with the loss of apoptosis regulation and abnormal cell proliferation." @default.