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- Bdc6b9c44390d2c48b4d097d88e8ab6eb NCIT_P378 "NCI" @default.
- Bdc6b9c44390d2c48b4d097d88e8ab6eb type Axiom @default.
- Bdc6b9c44390d2c48b4d097d88e8ab6eb annotatedProperty IAO_0000115 @default.
- Bdc6b9c44390d2c48b4d097d88e8ab6eb annotatedSource NCIT_C183321 @default.
- Bdc6b9c44390d2c48b4d097d88e8ab6eb annotatedTarget "A phosphate prodrug of PF-00835231, a broad-spectrum inhibitor of coronavirus 3CL protease (3CLpro), with potential antiviral activity against coronaviruses including severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) and SARS coronavirus-2 (SARS-CoV-2). Upon administration, lufotrelvir is converted to its active moiety, PF-00835231, which selectively targets and inhibits the activity of coronavirus 3CLpro. This inhibits the proteolytic cleavage of viral polyproteins and the formation of viral proteins including helicase, single-stranded-RNA-binding protein, RNA-dependent RNA polymerase, 20-O-ribose methyltransferase, endoribonuclease and exoribonuclease. This prevents viral transcription and replication." @default.